DEMOTO VET

DEMOTO VET

NON-NARCOTIC SEDATIVE AND ANLGESIC FOR HORSES

COMPOSITION
Detomidine Hydrocloride 10mg/mL


FEATURES AND BENEFITS
Detomidine is a non-narcotic sedative, analgesix, and muscle relaxant, with a rapid dose-dependent effect. Sedation may be expected within 1 - 5 minutes following intravenous injection (slightly longer following intramuscular administration). Full analgesic effect is expected 5 - 15 minutes after administration. A period of sedation is maintained for 0.5 - 6 hours, depending on the dose rate given.


INDICATIONS
DETOMO VET can be used in any situation requiring reliable sedation of horses, particularly if analgesia is also required. As a sedative, the dose can be altered to produce reliable variation in depth and duration of sedation. Examples of indications for use include sedation for diagnostic or radiographic procedures; dental procedures; transport and clipping.

Although DEMOTO VET causes reduced levels of consciousness, horses will remain standing (do not support the horse artificially - it will seek and find its own unsupported balance). Horses sedated with Detomo Vet experience fewer involutary gross motor movements (e.g. involuntary kicking) than experienced under other non-narcotic sedatives such as Acepromazine or Xylazine.

RADIOGRAPHY
Use a low dose of DETOMO VET (see dosage schedule) to aid positioning for xrays.

DIAGNOSTIC PROCEDURES
Which may cause discomfort or resentment, such as catheterisation, oral and ophthaimic examinations, rectal and vaginal investigations.

MINOR SURGERY
Including application and removal of casts, dressing changes, minor suturing, surgical procedures with local anesthetic. Use alone or in cojunction with narcotics such as butorphanol.

PRE-ANAESTHESIA
DETOMO VET may be used as a reliable pre-anaesthetic sedative. At recommended dose rates DETOMO VET will produce a potentiation of the effects of CNS depressant barbiturate anaesthetic agents. The dosage of such compounds should be correspondingly reduced and administered to effect. Post anaesthetic excitement has not been observed using DETOMO VET as the pre-anaesthetic agent.

COLIC
DETOMO VET is an effective analgesic sedative in the horse, with full analgesic occuring 5 - 15 minutes after administration. Like other alpha-2 adrenoreceptor agonists, some smooth muscle relaxation may occur when using DETOMO VET. Therrefore it is useful when cases of spasmodic colic have been diagnosed by the veterinarian. Do not use when colic is originating from literal or functional intestinal obstructions or from paralytic ileus. Withhold feed until the effects of the drug wear off. Failure of relief, or very short relief of pain following administration is often an indication of the need for surgical intervention in colics.


DOSAGE AND ADMINISTRATION
DETOMO VET can be given either intravenously or intramuscularly, as required. The effect is dose-dependent. The following scale can be used as a guide:

DEPTH OF SEDATION
Mild 0.5 - 1hr...DOSE(mL/100kg) 0.1 - 0.2...DOSE (mg/kg) 0.01 - 0.02
Moderate 1.0 - 2.0hr...DOSE (mL/100kg) 0.2 - 0.4...DOSE (mg/kg) 0.02 - 0.04
Heavy 2.0 - 6.0hr...DOSE (mL/100kg) 0.4 - 0.8...DOSE (mg/kg) 0.04 - 0.08

For analgesia in cases of spasmodic colic, give 0.2 - 0.4ml/100kg (0.02 - 0.04mg/kg). This table should be considered as a base from which dosage can be modified to effect, according to the depth and duration of analgesia or sedation required.


PRESENTATION
10mL sterile glass multidose vial for injection

STORAGE
Store below 25 celcius (air conditioning). Protect from light.